There is a market for Educational card games. Not the ones parents or teachers make kids play and tell them they are fun, but ones kids play because they want to.  For example think of a Pokemon game where the monsters are named and numbered after the elements of the periodic table, and the combat properties are based on the chemical properties of atoms.  There is no need to explain what these mean in terms chemistry. People will play and memorize it, if it is enjoyable. If the names and properties relate to real chemistry then to play the well, one will learn some chemistry. Here are two examples of periodic table Pokemon like card games.

Perodia a collectable card game that teaches the periodic table.​
 

 

Elementeo a non collectable card game (NCCG) that teaches periodic table.

The high energy physics game below is simpler and seemed aimed more at teaching first and fun second. The two biolgy games greatly simplify things.  I think a computer version of these games can increase both the learning potential and the fun of these games because the complexity can be kept in the back ground, where players do not have to memorize much to play, but playing lots will lead to memorizing and more importantly to learning some of the principles of the science.

Quark Matter is based on the elementary particle physics. The mechanics use particle compositions and decay paths.

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There are also games for biology.

Gene Pool is a an NCCG about gentic code

Familienbande uses genetic inheritance, is fun and simple but the science is very week.

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